ENODISE is an enabler project aimed at reducing aircraft gaseous and noise emissions by improving the integration of the propulsion system with the airframe. Complex aerodynamic and acoustic engine-airframe interactions are involved, which must be better understood to yield the expected gains. ENODISE will investigate the main propulsion-airframe integration issues at low TRL and build a solid basis of knowledge and methods based on simplified but representative configurations, permitting to assess a variety of integration concepts.